14. 09. 2018 Issue 64
A Stride in Developing Brain Regenerative Medicine

Professor Lau Kwok Fai of School of Life Sciences and his research team have found a new mechanism which stimulated a process called neurite outgrowth-the growth of nerve cell (neuron) projection.

The discovery casted a fresh light on developing strategies to stimulate neurite regeneration after nerve injury caused by traumatic brain injury (TBI) and in neurodegenerative disorders. The research finding was published in the Journal of Biological Chemistry, an authoritative journal of the American Society for Biochemistry and Molecular Biology.

 

Further Reading:
Kwok Fai Lau, Ho Yin Edwin, Jacky Chi Ki Ngo Chan, Wen Li, Ka Ming Vincent Tam, Wai Wan Ray Chan and Alex Chun Koon "Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1" in Journal of Biological Chemistry; DOI: 10.1074/jbc.RA117.000505

Prof. Kwok Fai Lau (front) and his research team find that increasing the presence of two types of proteins in the brain can potentially stimulate the growth of nerve cells and treat brain damage.

A schematic diagram illustrates the role of FE65-ELMO1 interaction. In a growth cone, FE65 recruits the complex of ELMO1 and DOCK180, and together they form FE65-ELMO1-DOCK180 complex. It is targeted to the plasma membrane to promote Rac1 activation and thereby neurite outgrowth.

Back to Issue
Table of Contents
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EVENTS
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Inauguration Ceremony for Undergraduate Students
Research Day 2018
JUPAS Interviews for Broad-based Science
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STUDENT ACHIEVEMENT
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Science students show talents at "Challenge Cup" National Competition Hong Kong Regional Final 2018
Innovation and Technology Scholarship Award Scheme 2018
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FACULTY ACHIEVEMENT
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Professor Yau Shing Tung has been honored Marcel Grossmann Award
Croucher Innovation Awards 2018
A Stride in Developing Brain Regenerative Medicine
Exemplary Teaching Award in General Education 2017
Research Excellence Award 2017-18 & Young Researcher Award 2017-2018
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UPCOMING EVENTS
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CALL FOR APPLICATION
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