A transformative progress has been uncovered in plant multivesicular body biogenesis and membrane protein vacuolar transport by Professor Jiang Liwen and his team. Combining empirical research with original theory, Professor Jiang newly identified a novel role and mechanism for plant-specific BRAF (BRo1-domain protein as FREE1 suppressor), which functioned as a unique evolutionary endosomal sorting complex required for transport (ESCRT) negative regulator in orchestrating intraluminal vesicle (ILV) formation in MVB/PVCs and the sorting of membrane proteins for vacuolar degradation in plants.
This pioneering discovery casted a fresh light on the improvement of crop quality allowing crops to overcome a stress environment or pathogen infection. This major advanced research result has been published in Nature Communications.
Jinbo Shen, Qiong Zhao, Xiangfeng Wang, Caiji Gao, Ying Zhu, Yonglun Zeng and Liwen Jiang. "A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis" in Nature Communication, 2018; DOI: 10.1038/s41467-018-05913-y
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