Atherosclerosis – also known as the “hardening of arteries” – is a major cause of stroke and ischemic heart disease. While there is no cure for the condition, existing treatments are either invasive, inefficient, or serve only to delay it from progressing. Although gene regulation is an emerging therapeutic approach, the delivery of therapeutic gene cargoes to atherosclerotic plaque sites still needs to be optimised. A team led by Professor Jonathan Choi Chung-hang, Associate Professor in the Department of Biomedical Engineering has developed a novel RNA nanoparticle to offer a potentially safe, effective treatment for atherosclerosis.
